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KMID : 0897520190240010029
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Journal of Korean Association of Social Psychiatry
2019 Volume.24 No. 1 p.29 ~ p.36
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Change of Psychiatric Symptoms and Adherence after Applying of Paliperidone Palmitate Long Acting Injection
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Park Hong-Jun
Kim Shin-Kyum
Byun Won-Tan
Jung Bong-Ju
Park Young-Min
Suh Jae-Won
Kim Se-Hoon
Lim Jong-Gil
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Abstract
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Objectives : Poor drug adherence is a major cause of symptom relapse in the overall course of schizophrenia. We investigated the change of psychiatric symptoms and drug adherence following paliperidone palmitate long acting injection (PLAI) in patients with schizophrenia.
Methods : Psychiatric symptoms and drug adherence were evaluated in 64 patients with schizophrenia at baseline and after 6-month use of PLAI. Korean version of Positive And Negative Syndrome Scale (PANSS) was used to evaluate the
change of symptoms and Drug Attitude Inventory-10 (DAI) to estimate their drug adherence. We assessed concurrent
dose of oral antipsychotics over time and associated treatment effectiveness with clinical variables.
Results : Psychiatric symptoms and drug adherence were improved after use of PLAI. Logistic regression analysis showed treatment effectiveness of psychiatric symptoms was associated with lower dose of initial oral antipsychotics and higher decrement of oral antipsychotics dose. And the improvement of drug adherence was associated with lower score of end-point PANSS-P.
Conclusion : PLAI is expected to be a promising strategy to reduce the dose of oral antipsychotics without worsening of psychiatric symptoms and drug adherence in schizophrenic patients.
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KEYWORD
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Paliperidone palmitate long acting injection, Schizophrenia, Drug Adherence, Positive And Negative Syndrome Scale (PANSS), Drug Attitude Inventory (DAI), Oral Antipsychotics dose
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